EGCG is the active constituent in green tea, a potent antioxidant. It also doesnt create a significant herx reaction/die-off reaction; it is well tolerated with good responses. Front Med (Lausanne). Beyond Balance has Lyme protocols, which are combination tinctures providing antimicrobial and detoxification support. I usually put Cats Claw in my protocols for Lyme, specifically Borrelia. It may be useful in treating Lyme symptoms such as arthritis and muscle pain, by enhancing the immune system. Some other herbs or drugs can also be consumed along the knotweed to enhance the medication required for the proper removal of Lyme causing bacteria. Its scientific name is Lyme Borreliosis. There are four protocols for Lyme that I have had good success with. You can even send a message about the hiccup, that would be awesome! This study provides the first convincing evidence that some of the herbs used by patients, such as Cryptolepis, black walnut, sweet wormwood, cats claw, and Japanese knotweed, have potent activity against Lyme disease bacteria, especially the dormant persister forms, which are not killed by the current Lyme antibiotics, says study co-author Prof. Ying Zhang. Japanese Knotweed, I always use that one. Study 1: Cooperation of Doxycycline with Phytochemicals and Micronutrients Against Active and Persistent Forms of Borrelia, Source: Goc, Anna & Niedzwiecki, Aleksandra & Rath, Matthias. The active ingredient in Ghanaian quinine is an alkaloid called cryptolepine, which people have traditionally used against malaria, hepatitis, septicemia, and tuberculosis. Top on the list was Cryptolepis, behind that Japanese knotweed, cat's claw, Chinese skullcap, artemisia, black walnut, Cistus incanus, which is actually more of an essential oil, Andrographis, stevia, grapefruit seed extract, and monolaurin. If there are such good herbs and other treatments suggested, then it would be great to have something to follow. He eats mostly Paleo, organic foods and herbs and supplements, but I believe it is the biofilm that hides from all treatments. Important compound in Japanese Knotweed. Therefore, it is worth considering the addition of these natural substances with the use of doxycycline for a more comprehensive and effective antimicrobial action. The active constituent has been documented to have activity against the stationary form of Borrelia. doi:10.2147/IDR.S19201(, Sharma B, Brown AV, Matluck NE, Hu LT, Lewis K. Borrelia burgdorferi, the causative agent of Lyme disease, forms drug-tolerant persister cells. Japanese knotweed (pictured above) is one of the two plants whose active compounds appear to be highly effective against the bacterium that causes Lyme disease. Artemisinin has documented activity against stationary phase of Borrelia burgdorferi, It has been shown to reduce short term memory impairment when combined with IV ceftriaxone in patients with Lyme Disease, This herbal is also a potent anti-parasitic, Scutellaria Baicalensis (Chinese Skullcap), Chinese Skullcap has neuroprotective, antioxidant, and anti-excitatory activity, Its active constituent Baicalein is responsible for these benefits, Baicalein has been shown to have activity against the various forms of Borrelia burgdoferi including log phase, latent round bodies, and biofilm formation, Calming due to its activity on GABA receptor, Supportive herb and provides protection for mitochondria, Decreased BCL-2 and increased BAX in brain, Reduced ischemia/reperfusion damage in brain, Great for anxiety, aggression/rages, sleeplessness and neurological symptoms from Lyme and Lyme Co-Infections, Anti-inflammatory and immunomodulatory benefits, Start with DETOX 2 Then introduce tincture starting low (1 DROP) and slowly increase, Provide antimicrobial and detoxification support, All in glycerite form so taste is better tolerated, Start low (1 DROP) and increase up as tolerated, Monthly protocol that utilizes 14 NutraMedix products on a rotational basis, Products are taken daily according to a set schedule, . Join us by subscribing to our newsletter. I am hoping all those abx help you. Most of the doctors on our PANS PANDAS list deal with PP and some deal with lyme. Brilliant, informative article. Sometimes, however, antibiotics are not effective in eradicating all traces of B. burgdorferi from the system, which means that the disease can persist. Herbs that are antimicrobial will likely set off a herxheimer reaction. Artemisia, also known as sweet wormwood, has been used medicinally for over 2000 years. Selective Essential Oils from Spice or Culinary Herbs Have High Activity against Stationary Phase and Biofilm Borrelia burgdorferi. I did Japanese Knotweed in tincture form. To help justify these various antimicrobial options, in this section I describe the experimental basis behind my recommendations. . It activates Sirtuin Genes, imitating the functioning of a calorie-restricted diet. There are some articles and good research is done on herbals, Lyme and Tick-borne infections. Antibiotics are the standard of care for Lyme disease treatment. 2019;8(2):72. doi:10.3390/antibiotics8020072(, Ma X, Leone J, Schweig S, Zhang Y. Botanical medicines with activity against stationary phase Bartonella henselae. how long have you been on the protocol Questing? With low G6PD there is a risk that your red blood cells will break apart. The next is a Chinese Skullcap, Scutellaria baicalensis, one of my favorite herbs. Herbalist Stephen Buhner recommends using a Japanese knotweed supplement in his book Healing Lyme and notes that it is the only herbal treatment that blocks the bacterial phyla known as spirochetes, which lead to Lyme disease and other infections like bartonella. Published July 2010. It is by no means comprehensive. J Neuroinflammation. For more information on this read Disulfiram. Historically, dapsone is used to treat Leprosy. Suggested dosage: 200-800 mg Japanese knotweed (standardized to 50% trans-resveratrol) two to three times daily. Woman 50 years old, just diagnosed with Borrelia Myiamotoi and Group af Relapsing Fever. I have been referred to numerous specialists (Endocrinologists, Neurologists, etc.) J Clin Exp Dermatol Res. Continue treatment with antibiotics until you are well. This has been an extremely depressing six months in our lives. This article was comprehensive and thorough. There is no evidence to suggest that Lyme disease is contagious among humans. That is just suggested as a range. You will need to take an enzyme to help dissolve the biofilm of the cysts, in order for the Lyme to be killed off. In my practice, I often mix herbal and prescription options together. Note: disulfiram does not appear to treat Bartonella. The book says it should contain 500mg of the Polygonum cuspidatum, but the bottle says 200mg. https://www.ilads.org/patient-care/provider-search/, Hi I live in Australia and like so of the people with Lyme disease, my son has struggled for over 25, years, physically, financially, and mentally. Use Japanese knotweed with caution with blood thinning medications and discontinue the use of the herb 10 days prior to surgery. Resveratrol is the antioxidant in red wine that got a lot of good press. 500 mg of amoxicillin is a very high dose, which is four times stronger than physicians prescribe for other infections, such as ear infections. Similar to disulfiram, dapsone-based treatment is a harsh regimen with nearly 40 percent of people dropping out of treatment due to side effects. Based on my observations, these herbal combination options have as good of a chance as the prescription options. Clinically, I find it to be great for anxiety for aggression and for or those who have sleep disruptions and neurological symptoms from Lyme and co-infections. RESVERATROL ~ 2 capsules a day (400-500mg total per day) Try Garden of Life Raw trans resveratrol. Just starting taking it. Essentially what happens is that the baseline symptoms intensify. Selective essential oils from spice or culinary herbs have high activity against stationary phase and biofilm Borrelia burgdorferi. Some other herbs or drugs can also be consumed along the knotweed to enhance the medication required for the proper removal of Lyme causing bacteria. Even a year or more into treatment, when a person is feeling better, these steps are essential to speed recovery by supporting the immune system. Many physicians have different ways of pulsing antibiotics. It is a very good source of resveratrol, and most benefits of Japanese Knotweed may actually just be benefits of resveratrol. LYME disease researchers are exploring the medical properties of Japanese knotweed, suggesting plant-based drugs could be a better treatment than antibiotics. Thank you very much! I recommend disulfiram-only regimens to people who have taken extensive numbers of antibiotics for a year or more of treatment and remain ill. It found multiple herbals that are safe and have potential potent antimicrobial benefits against the persister form of Borrelia burgdorferi. Japanese knotweed (Polygonum cuspidatum) is an invasive species in New York state. I started with 1 drop and slowly went up to 2 droppers full, 3 times a day. My German Shepherd has Lyme Disease. Dr. Zhang and colleagues have also shown that Japanese knotweed treats growing and persister states of Lyme and Bartonella. It is considered to be the most effective herbal way to lower, or even eliminate Lyme disease and its symptoms. They appear to kill intracellular and extracellular Lyme, too, based on the clinical benefit I see in my medical practice. ive been doing Jk root powder, as per Buhner's latest recommendation- it does not taste good, i mix it into lemon water with stevia and sometimes with a green grass smoothie- if done like this its ok.the stevia helps alot.you also got to stir it for about. I live in Norway, North Europe. For her complete bio and more information, please see her website. The following are four general rules I use to develop a Lyme disease antibiotic regimen: Be aware the doses I provide below are for adults. Treating Borrelia, the Lyme germ, with antibiotics is complicated because limited research shows which treatment regimens work best. Sida Acuta, I dont use it as often because some people have a reaction to it; you should work with a practitioner if you choose to add it. Lyme disease is an infectious disease caused by the bacterium Borrelia burgdorferi (B. burgdorferi). It let us know that we are actively addressing the underlying infections, but my goal is never to make children or families uncomfortable. Drug Des Devel Ther. I hope you can see a lyme literate doctor. With Optimism, life is good! I know you're not doing caps or tablets, but it shows that the bart dosage is about in the 'middle ground' of the lyme dosage. The capillary stimulant action is of specific importance in Lyme treatment as it increases the blood flow to areas where the Lyme spirochete likes to live such as the eyes, skin, heart and joints. It is one of my go-to herbals for Babesia, a common co-infection. Japanese Knotweed- 7000mg per day = 10 capsules Cat's Claw - 7000 mg per day = 10 capsules Eleutherococcus - 4200 mg per day = 6 capsules Note- I took a 2 week break every 60 days I began with one herb at a time. If someone has a co-infection, when possible, I choose antibiotic combinations that simultaneously treat Lyme germs and the co-infection germs. In the book, you recommend Japanese knotweed. When you start to kill them off using different herbs or antibiotics, these germs release biotoxins that alert their friends that something is going to kill them. I prefer the pink Himalayan sea salt because there can be some traces of iodine in there. Note: I work with the following anti-cyst agents based on the mechanism by which these antibiotics work and some scientific experiments. What Does Japanese Knotweed Do For The Lyme? Although the current recommended Lyme antibiotic treatment is effective for the majority of Lyme disease patients, about 10-20% of patients continue to suffer from persisting symptoms. This new study came out in February 2020. Disulfiram (tetraethylthiuram disulfide) in the treatment of Lyme disease and Babesiosis: Report of experience in three cases. The Spirochete bacterium enters into the bloodstream, when a tick infested with Spirochete bites a human. Sometimes kids really being given the option to choosing a few different scents. Richard Horowitz, MD has promoted the use of dapsone-based regimens to treat both Lyme and Bartonella persisters. He has a great book, Healing Lyme. When this happens, bacterial cells that have developed antibiotic resistance can continue to proliferate. However, I have seen wonderful recoveries for many on herbal antibiotics, so I assume the ones I recommend in this article help with intracellular Lyme. The following prescription and herbal medicine options have been shown in lab experiments to kill persisters, which I am incorporating into my treatments of Lyme and/or Bartonella. Large quantities of Knotweed can act as a gentle laxative. I stir it for 3-5 minutes at least and it never all dissolves. Infect Microb Dis. Identification of new drug candidates against Borrelia burgdorferi using high-throughput screening. This infectious disease is caused via the bite of an infected tick. Its vital to be properly diagnosed, I knew I had Lyme and the battery of doctors that were illiterate yet diagnosed and prescribed is shameful. If you experience any issues, please bear with us. Before I dive into how you can starttreating Lyme bacteria with Japanese Knotweed, lets have a closer look atwhat Lyme disease is: Lyme disease is an infectious disease caused by species of bacteria from the genus Borrelia. Family members benefit from education and tools to support Lyme sufferers. 2016;10:13071322. The essential oils are added to treat persister Lyme. As an alternative, ceftriaxone could be given daily as 2 gm IV 1 time a day. I am so sorry. We are not able to provide direct medical advice or provide a treatment plan. Made with wildly foraged teasel root and gluten free alcohol. Next is Cryptolepis is definitely becoming one of my favorite herbals to be used for my PANS kids. It decreases B-cell lymphoma 2, known as BCL-2. Japanese Knotweed is very popular for treating Lyme. Macrolides (like clarithromycin) and tetracyclines (like doxycycline), work in the intracellular and extracellular spaces. Dear Stephen, I have a question about dosages of the lyme protocol. For maintenance use the species appropriate product. we are planning to do doxycycline for 4 weeks with herbal on side (starting 1 drop and increasing) I so appreciate your response. New research has found a narrow-spectrum antibiotic that is effective against Lyme disease. Byron White recommends starting is using Detox-2, which is a binder. There is so much good information out there, but confusing. I'm on Flagyl, so I can't do any alcohol based tinctures. It is a combination product with aloe, pectin, zeolite clay, and activated charcoal that helps to bind biotoxins to get them out of the body to decrease inflammation and other die-off symptoms. Treatments include antimicrobials that address persisters, in addition to the growth phase. The scientific name for this plant is Fallopia Japonica. 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