role of copper in vitiligorole of copper in vitiligo

Would you like email updates of new search results? Vitiligo is neither contagious nor life-threatening. Therefore, copper supplementation alone may not be sufficient to reverse the condition entirely. Individuals with vitiligo are more susceptible to sunburn and skin cancer, hair loss, eye problems, and psychological distress. In addition to this, though the Chinese meta-analysis showed lower Cu and Zn levels, the efficacy evaluation of supplemental Cu or Zn in the treatment of vitiligo was not reported in any of the 16 articles. Vitiligo benefits and uses of coconut oil, http://www.vitiligostore.com/boost-tanning-supplement.html, https://thevitpro.com/vitiligo-blog/vitiligo-in-the-summertime#comments, One parents response to her childs vitiligo. 0000001952 00000 n Your email address will not be published. Melanin, a natural pigment of skin, requires amino acid tyrosine for its synthesis. The most common treatments include drugs that affect immune system, light therapy (skin re-pigmentation), and surgery (skin grafting and micropigmentation). Conclusions: In our study the lesional and non-lesional Cu levels were lower in vitiligo patients. . Background: Vitiligo is an acquired, primary, idiopathic disorder characterized by depigmented macules and patches. Many sources can be listed to confirm that certain metal ions including copper are found in high levels in pigmented tissues involved in melanin synthesis. xref A second explanation of the metabolic disorders in vitiligo might be the role of eventual inhibitor(s) discussed by Fitzpatrick and coll13. It was suggested that trace elements may play a role in pathogenesis of vitiligo. Copper ions traveling to different parts of the skin can help the body rectify the effects of vitiligo naturally. Vitamin Supplementation for Vitiligo. The correlations between the quantitative variables were assessed by scatter plots first and then Pearsons or Spearmans correlation coefficients were calculated. More info. Segmental vitiligo, where patches appear only on one side of the body. 0000001984 00000 n But, it has been established that copper is another cofactor in melanin production, and many patients with vitiligo are found low in it. Recent studies have shown that individuals with vitiligo have lower copper levels in their blood and skin compared to those without the condition. While experiment- However, Shameer et al. ginkgo biloba. Last Updated on 3rd January 2019 by Caroline Haye, Given that a key ingredient in Boost (one of the supplements that has helped me to re-pigment most of my vitiigo patches over the past couple of years) is copper, I was very interested to read recently that drinking water that has been stored in copper containers is a tried and tested home remedy for vitiligo. The metanalysis concluded that decreased levels of serum Cu and Zn generally exist in Chinese vitiligo patients. Vitiligo is a genetic and autoimmune skin disorder in which skin loses its natural color due to lack of pigmentation. The condition can affect the skin on any part of the body. may email you for journal alerts and information, but is committed Vitamin D increases the rate of melanogenesis by increasing the activity of tyrosinase. Arya M, Roy PR, Mandol SR. Studies of serum and skin copper levels in vitiligo. Al-Rubayee WTS. However, not everyone agrees on the role of melanin in vitiligo. 2022. Journal of the Indian Medical Association 1961;37:593-7. How are Women Emotionally Affected After a Hysterectomy? Copper supplementation should only be done under the supervision of a healthcare provider, and routine monitoring of copper levels is recommended to avoid the risk of copper toxicity. Depending on the locations of patches on the body, vitiligo can be divided into three main categories: The diagnosis mainly depends on evaluating patients medical history as well as their family history of vitiligo incidents. Please enable scripts and reload this page. These values were statistically insignificant (P-value<0.05) [Figure - 1]. Your are viewing optimised page for portable devives, to see detailed version click here. Tu CX, Lin XR, Yin F. Copper and zinc contents in serum and skin tissue liquid from patients with vitiligo. It appears that rhododenol, an active ingredient in the product that is also a phenol that resembles tyrosine, is responsible for inducing vitiligo in those that used the product. Savitha, B. Jayadev, P.A. Several theories have been proposed so far to unravel the complex vitiligo pathogenesis. Hence, the levels of these two elements are not interdependent on each other. The 95% confidence range for Zn and Cu was calculated using the reference range [Table - 1] for these variables. [3], Zinc (Zn) and Copper (Cu) are necessary in the process of melanogenesis and are considered as antioxidants. [9] showed that the levels were significantly higher in active vitiligo patients compared to controls. The mean serum Zinc was low whereas Cu was higher when compared to controls but the actual range of levels of Zn and Cu from patients and controls were much higher than the reference range. Understanding the Role of Epigenetics in Cancer. Egypt J Hosp Med 2018;70:273-81. As for subgroups of vitiligo, four studies investigated them and indicated that their levels had no relationship with skin lesions, disease course, progression, damaged skin areas or age of vitiligo. Subtypes of Vitiligo Can you self-identify the one you have? Fill in your details below or click an icon to log in: You are commenting using your WordPress.com account. During studies, it is found that the copper content of the skin is concentrated mainly in the epidermis. Accessibility S.A. Archana, Vinutha Rangappa, T.G. By clicking "Allow All" you agree to the storing of cookies on your device to enhance site navigation, David Paltrow, an unconventional vitiligo researcher, has recently hit the news with his claim that he has discovered the real cause of vitiligoaccording to him, it has nothing to do with melanin. Chim. Circumcised vs. Uncircumcised; Differences in the Penile Microbiome, New AI-based method for virtual staining of histopathological tissue samples, Adding structure to the school holiday can help keep kids active and healthy, UniSA nursing lecturer warns about sudden deafness after COVID-19 infection. Dermatologists were among the first to identify the emotional component of a physical illness. However, the condition is often stressful, and people may undergo serious depression in some of the worst cases. Introduction: Vitiligo is a chronic skin disease, which its etiopathogenesis is not fully understood. doi: 10.1111/dth.12625. government site. Moreover, various factors affect Zn and Cu levels in serum, so empirical treatment with Zn and Cu supplements increases the cost of treatment and is not supported by evidence. Keeping in mind that copper stimulates the melanocytes into action, increases melanin and re-pigments the skin, researchers across the globe have attempted to evaluate the role of copper status in the treatment of vitiligo. Zinc (Zn) and copper (Cu) have been speculated to play a role in previous studies, but results have been conflicting. https://thevitpro.com/vitiligo-blog/vitiligo-in-the-summertime#comments. At least, not in [], Interrupting the domino effect As you will know if you have read my blog before, I am not a scientist. This is worth checking through a blood test, and supplementing with the mineral if the skin disorder can be slowed down with maintaining proper copper level. Mean lesional Cu was 1.3g/g and non-lesional Cu was 1.4g/g in vitiligo patients, which was lower than tissue Cu levels of controls(1.9g/g) (p value > 0.05). Although the exact cause of vitiligo is unknown, researchers have suggested that multiple factors, including genetics, oxidative stress, and autoimmune processes, may contribute to its development. Many people get a healthy amount of copper by drinking a . This low Cu levels may lead to reduced activity of enzyme tyrosinase, which is essential in the process of melanogenesis. I started writing this blog as a way of sharing my own personal story of what it is like to have lived with widespread vitiligo, only to recover most of my pigment again. Results: Of 60 patients, serum Cu levels in cases were found to be low in 35, normal in 22 and high in 3. Nutritional deficiencies are known to alter melanin production. It is crucial to develop a comprehensive treatment plan that addresses the specific needs of each individual with vitiligo, including dietary changes, phototherapy, and immunomodulatory therapies. J Clin Med. A systematic review of natural health product treatment for vitiligo. Copper is also a crucial component of numerous enzymes involved in melanin production, which gives color to the hair, skin, and eyes. Indian J Dermatol Venereol Leprol 1978;44:281-85. Zeng Q, Yin J, Fan F, Chen , Zuo C, Xiang Y. Saleem MA, El-Raheem TA, Aboraia NM. Is Coconut Oil Good For Vitiligo With or Without Psoralen Treatment? Vegetarians constituted 27 out of 100 cases (27%), whereas 73 (73%) were non-vegetarians. Garg BJ, Saraswat A, Bhatia A, Katare OP. Some researchers suggest that the treatment with Cu and Zn in skin diseases could be successful in cases of primary Cu and Zn deficiency but the effectiveness of oral Cu and Zn supplements could be limited if they were in a sufficient amount in the body. News Medical spoke to Michele Hu,Consultant Neurologist at Oxford University Hospitals and Professor of Clinical Neuroscience at the Nuffield Department of Clinical Neurosciences, University of Oxford, about prodromal Parkinson's and what the future looks like for this neurological disease. Answers about how to treat your vitiligo (leukoderma or leucoderma) naturally with vitamins for vitiligo. degree and a Master's of Science (M.Sc.) Hence, further studies are needed to determine the pathological nature of copper status in those living with vitiligo. 2023The Vit Pro (A Vitiligo Blog)All rights reserved, Powered byWPDesigned with the Customizr Theme, Click to share on Twitter (Opens in new window), Click to share on Facebook (Opens in new window). Tsiskarishvili N. Cuprum sulfate and vitix in the treatment of vitiligo in children. In a Chinese meta-analysis of 16 studies, by Zeng et al,[4] 14 studies evaluated serum Zn within which four studies reported no statistically significant difference in Zn levels between the vitiligo group and the healthy group, ten studies presented significant decrease and none found increased Zn levels. Oxid Med Cell Longev. Vitamin Supplementation for Vitiligo. [8] showed no significant relationship between serum Zn levels and age. Materials and Methods: All cases of vitiligo attending tertiary care hospital were included in the study. Stable Vitiligo was found in 32 out of 100 cases (32%) and unstable in 68 cases (68%). While drinking water from a copper vessel is known to be highly beneficial, wearing a copper bracelet is another effective way to increase copper levels in the body. Dutta, Sanchari Sinha. %%EOF 0000000016 00000 n IOB researchers identify an active multi-layer embryonic brain circuit. This is most effective when vitiligo is still in its early stages. 0000001772 00000 n Koranne RV, Derm D, Sachdeva KG. The bracelets contain embedded earth magnets of different sizes. Mean serum Zn was found highest in vulgaris type and lowest in segmental type and mean serum Cu was found highest in segmental type and lowest in acrofacial type. Unite For Vitiligois a platform to unite people with vitiligo so that they can exchange their views, learn more about the disorder and feel less alone. Copper is essential for the melanin production in man. Mean duration was 6.7 years. Molokhia MM, Portnoy B. Supplementing with copper can benefit vitiligo patients with deficiency and slow down the progression of the disorder. startxref Im not a trained nutritionist so I cant give you details of the exact levels of copper you are likely to need. More studies are required to clarify role of Zn and Cu as well as other antioxidants in pathogenesis and treatment of vitiligo considering the various nutritional and environmental factors.

Elm Tree Seed Pods, James Darren 2020, Is Stanley Dunham Related To George Bush, Articles R