Tianeptine is also known as Tianaa or Tianeptine sulfate and is a prescription drug in other countries. In the meantime, the Harvard researchers have released the names of the products that tested positive for BMPEA, so you can steer clear. 2015 Jun 16;162(12):879-80. doi: 10.7326/L15-5101.View abstract. Remarkably, BMPEA was still an ingredient in 52% of the supplements tested (11 out of 21). Creatine has also been linked to an increased risk of compartment syndrome, a condition where pressure builds in a muscle compartment and prevents blood flow. -Methylphenylethylamines: common fragmentation pathways with amphetamines in electrospray ionization collision-induced dissociation. According to Consumer Reports, BMPEA was found in the following weight-loss supplements: BMPEA was also found in the following sports supplements: The Schmidt Firm, PLLC is currently accepting supplement induced injury cases in all 50 states. J Pharmacol Exp Ther. Overview Information. Common Supplements containing Tianeptine: https://www.fda.gov/food/dietary-supplement-products-ingredients/tianeptine-dietary-supplements. Retrieved 29 May 2019 from https://pubchem.ncbi.nlm.nih.gov/compound/2-Phenylpropylamine, Pawar, R. S., Grundel, E., Fardin-Kia, A. R., & Rader, J. I. doi:10.1007/s00216-014-7728-5, Cohen, P. A., Bloszies, C., Yee, C., & Gerona, R. (2016). Should You Worry About Artificial Flavors Or Colors? Other names include Octodrine and 1,5-DMHA. Putting discussion of the need for proper testing and labeling aside, is the appearance of this new drug really unexpected? View abstract. Dietary Supplements for Exercise and Athletic Performance (ODS), Bodybuilding - Systematic Reviews/Reviews/Meta-analyses (PubMed), Dietary Supplements Marketed for Weight Loss, Bodybuilding, and Sexual Enhancement, Bodybuilding - Randomized Controlled Trials (PubMed), U.S. Department of Health & Human Services, 9000 Rockville Pike Bethesda, Maryland 20892, U.S. Department of Health and Human Services. ACSH does not have an endowment. 2021 Mar 22;20(2):328-38. Available at: https://www.fda.gov/Food/DietarySupplements/QADietarySupplements/ucm443790.htm. This product does not meet the FDAs definition of a dietary supplement ingredient, and any supplement product containing this ingredient is considered adulterated and illegal. Ephedra is also known as Ephedrine and ephedra alkaloids. BMPEA is a chemical that stimulates the body. FDA has issued awarningstating, BMPEA does not meet the statutory definition of a dietary ingredient. Therefore, dietary supplement products with BMPEA are misbranded and cannot be sold as dietary supplements. And this has happened before with a different synthetic stimulant: ephedrine. Drug Testing and Analysis, 9(1), 135142. doi:10.1002/dta.1976, Cohen, P. A., Travis, J. C., Keizers, P. H. J., Deuster, P., & Venhuis, B. J. Salvia divinorum, also known as Sally D, has three common forms Salvia divinorum, Salvia hispanica, and Salvia miltiorrhiza. Dietary supplements promoted for weight loss encompass a wide variety of products and come in a variety of forms, including capsules, tablets, liquids, powders, . Associate Professor of Population Health, New York University. Phenethylaminesrefer to a class of substances with documented psychoactive and stimulant effects and include amphetamine, methamphetamine and MDMA, all of which are controlled under the 1971 Convention. Theres no clear evidence these supplements improve athletic performance. A Chemist Chats with ChatGPT. European Journal of Pharmacology, 859, Article 172515. doi:10.1016/j.ejphar.2019.172515, Schindler, C. W., Thorndike, E. B., Rice, K. C., Partilla, J. S., & Baumann, M. H. (2019). BMPEA is often labeled as Acacia rigidula on labels and is currently considered misbranded. It is illegal in supplements and therefore banned by the military. Dr. Levine agrees, Youve got a mechanism and biological plausibility: we know that other drugs in this class do this. Common Supplements containing Acacia Rigidula: https://www.opss.org/article/acacia-rigidula-it-legal, https://www.webmd.com/vitamins/ai/ingredientmono-1411/acacia-rigidula. Undeclared doping substances are highly prevalent in commercial sports nutrition supplements. Cohen PA, Zeijlon R, Nardin R, Keizers PH, Venhuis B. Hemorrhagic Stroke Probably Caused by Exercise Combined With a Sports Supplement Containing -Methylphenyl-ethylamine (BMPEA): A Case Report. COPYRIGHT 1978-2022 BY THE AMERICAN COUNCIL ON SCIENCE AND HEALTH. It is considered a stimulant and can have adverse effects. History full circle: Novel sympathomimetics in supplements. Users who took the recommended amount of the supplement could be exposed to up to 94-mg of BMPEA per day. (2014). Second and more importantly, it may be an adulterant that turns out to be too dangerous for the average person to consume. Selective androgen receptor modulators (SARM) are synthetic drugs that have a similar effect to testosterone. It can be made synthetically or found in the plant Cannabis sativa (marijuana, hemp). "These are things that are signals that . Because of this, it is often added to products for weight loss and athletic performance. An amphetamine isomer whose efficacy and safety in humans has never been studied, -methylphenylethylamine (BMPEA), is found in multiple dietary supplements Pieter A. Cohen, Corresponding Author Pieter A. Cohen Department of Medicine, Harvard Medical School, Boston, MA, 02115 USA Cambridge Health Alliance, Somerville, MA 02143 USA It might increase blood pressure and heart rate. Aromatase Inhibitors are also known as Arimistane and ATD. Products containing the stimulants BMPEA or DMAA can cause serious health problems. The FDA did not issue any consumer warnings. Epub 2014 May 6. (2016). Soldier use of dietary supplements, including protein and body building supplements, in a combat zone is different than use in garrison. Know the Science: 9 Questions To Help You Make Sense of Health Research. BMPEA in dietary supplements. Brown DH, Hansson R, Oosthuizen F, et al. Pawar RS, Grundel E, Fardin-Kia AR, Rader JI. Retrieved 1 May 2019 fromhttps://www.fda.gov/food/dietary-supplement-products-ingredients/bmpea-dietary-supplements, Yun, J., Kwon, K., Choi, J., & Jo, C.-H. (2017). The presence of BMPEA was confirmed by . Some dietary supplement products actually list BMPEA (often using one of the terms listed above) on their labels. FDA's Silly 'Healthy' Food Labels, Podcast: Erythritol Probably Doesn't Cause Heart Disease; Dietary Supplements Can Kill, Why Do Books Smell? If people were using BMPEA to get high (if it is even possible) instead of using it for fitness purposes, it would be a different story and the Drug Enforcement Administration (DEA) would likely step in to control use. 2020. Known by its longer chemical name, -methylphenethylamine, BMPEA is achemical relative of amphetamine thatsmore likely to affect blood pressure than act as a stimulant. https://www.opss.org/article/igf-1-it-banned. Knapik JJ, Steelman RA, Hoedebecke SS, et al. Beta-methylphenethylamine (BMPEA) is a stimulant chemical that is made in the lab. A service of the National Library of Medicine, PubMed contains publication information and (in most cases) brief summaries of articles from scientific and medical journals. However, DMAA is still found in some products marketed as supplements, including under different names, such as geranium oil. In particular, sports supplements appear to be widely used with younger age groups, and the potential for serious harm should not be underestimated. Other contributors to the case report published today in Annals of Internal Medicine include Rickard Zeijlon, MD, of Sahlgrenska University Hospital in Gothenburg, Sweden, where the case originated; Rachel Nardin, MD, of Harvard Medical School; and Peter H.J. Information from this source is evidence-based and objective, and without commercial influence. doi:10.1002/dta.1793, Cohen, P. A., Avula, B., Venhuis, B., Travis, J. C., Wang, Y.-H., & Khan, I. It is marketed as being able to improve certain heart conditions and nerve or joint pain. Reverso Context: As of Tuesday night, the death toll had risen to 121, but 181 were still missing.-"As of Tuesday" The U. S. Food and Drug Administration determined that BMPEA is not naturally present in food and does not meet the statutory denition of a dietary ingredient. Picamilon, also known as Pikatropin, is a prescription drug in Russia made of a combination of niacin and GABA. In the human brain, 2-phenethylamineis believed to function as a neuromodulator or neurotransmitter (a trace amine). Although some supplements may not be illegal, they may not pass the militarys strict rules on supplement use. . . Source: Nine prohibited stimulants found in sports and weight loss supplements: deterenol, phenpromethamine (Vonedrine), oxilofrine, octodrine, beta-methylphenylethylamine (BMPEA), 1,3-dimethylamylamine (1,3-DMAA), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylbutylamine (1,3-DMBA) and higenamine Clinical Toxicology DOI: Especially, -methylphenylethylamine (BMPEA), an amphetamine isomer, has been found in dietary supplements labeled as containing Acacia rigidula.The U. S. Food and Drug Administration determined that BMPEA is not naturally present in food and does not meet the . Schindler CW, Thorndike EB, Rice KC, Partilla JS, Baumann MH. Accessed at, Office of Dietary Supplements website. A little over a decade ago the major dietary supplement of concern in the US was ephedrine (an alkaloid found in ephedra). Because the safety of this ingredient is questionable, Dr. Cohen recommended immediate action by the FDA: Consumers of Acacia rigidula supplements may be exposed to pharmacological dosages of an amphetamine isomer that lacks evidence of safety in humans. (2023). MRI and cerebral angiography showed no other types of blood vessel abnormalities or inflammation (vasculitis). Studies have looked at a variety of supplements used for bodybuilding or to improve physical performance, including glutamine, choline, methoxyisoflavone, quercetin, zinc/magnesium aspartate, nitric oxide, and L-arginine. Ephedrine products were also sold as legal replacements for other illicit drugs in the late 1990s. (Skip to this section) BMPEA is safe, as documented by nine research studies performed on supplements with the ingredient.. Required fields are marked *. In the ER, wed be seeingpeople who did crack cocaine for the first time and had a stroke. -- Dietary supplements labeled to contain a shrub called Acacia rigidula actually contained a speed-like compound called BMPEA instead, according to a new study, prompting Vitamin Shoppe has announced that it will no longer sell products that contain Acacia rigidula, the national vitamin store chain announced Wednesday. Although it is not currently a controlled substance, it is banned because of its effects and because it does not have an approved medical use. She had stopped smoking 22 years earlier and reported that this incidence was the first time she used a workout supplement. In 2017 the Food and Drug Administration (FDA) tested 21 supplement products with the ingredientAcacia rigidulalisted on the label and found that 9 of the 21 products contained BMPEA, which is not derived from the plantAcacia rigidula. BMPEA, in relatively high doses of 960-60,500g/g, was also found to have these effects. Brown, D. H., Hansson, R., Oosthuizen, F., & Sumner, N. (2015). It appears that BMPEA is intentionally added to these supplements for its stimulant properties and since it is not listed on the labels of these products, consumers have been unknowingly ingesting this untested stimulant. It was developed as a treatment for neural conditions and is marketed as a nootropic (cognitive enhancer) dietary supplement. Accessed at, Office of Dietary Supplements website. Is phenylethylamine a controlled substance? Terjung RL, Clarkson P, Eichner ER, et al. (2018). This information may not fit your specific health circumstances. an amine that occurs naturally as a neurotransmitter in the brain, has properties similar to those of amphetamine, is an antidepressant, and is found in chocolate. Know the Science features a variety of materials, including interactive modules, quizzes, and videos, as well as links to informative content from Federal resources designed to help consumers make sense of health information. Common Supplements containing Cannabidiol: https://www.opss.org/article/cannabidiol-are-products-cbd-legal, https://www.fda.gov/news-events/public-health-focus/fda-regulation-cannabis-and-cannabis-derived-products-including-cannabidiol-cbd#dietary_supplements. It's similar to amphetamine and may be illegally included in some supplements. Drug testing and analysis. Dangerous hidden ingredients are an increasing problem in products promoted for bodybuilding, the U.S. Food and Drug Administration (FDA) warns. A total of 110 dietary supplements advertised as weight-loss, fat-burning, energy-enhancement, or athletic-performance enhancement were purchased from the internet websites from 2015 to 2016. Stimulants, such as amphetamines and cocaine, speed up the nervous system. Mysterious Case of Diver Who Stabbed Himself. Kratom will not give a positive result on a routine DoD test, but it is discouraged from use by the military because of its safety concerns relating to side effects, potential death, or addiction. Onestudyfound that up to 4 years after the FDA recalled some supplements, two-thirds still contained the prohibited drugs. In 2004, the Federal Drug Administration (FDA) banned ephedrine from dietary supplements as it was deemed an unreasonable risk to public health. The supplement adulterant -methylphenethylamine increases blood pressure by acting at peripheral norepinephrine transporters. The FDA states that CBD products cannot be sold as dietary supplements, so products advertised as dietary supplements are illegal. 'Adam and Heave' - Is Akee the Real Forbidden Fruit? BMPEA is commonly used for weight loss and to improve memory and exercise performance. Neurochem Res 2013;38:842-6. https://www.fda.gov/drugs/medication-health-fraud/questions-and-answers-hcg-products-weight-loss, https://www.opss.org/article/hcg-it-legal-supplement. (2017). Shortly after the ephedrine ban another potentially dangerous stimulant called methylhexaneamine (DMAA) also popped up in supplements and the FDA stopped companies from selling these products. Also, the military has banned any use of products containing CBD under the Uniform Code of Military Justice. There have been reports that creatine may impair liver and kidney function. Pune, Feb. 06, 2020 (GLOBE NEWSWIRE) -- The global Dietary Supplements Market size is expected to reach USD 74.14 Billion by 2026, exhibiting a CAGR of 6.34% during the forecast period. Phenethylamineis POSSIBLY UNSAFE for most people when taken by mouth appropriately. Anal Bioanal Chem 2014;406:3681-8. So, the threshold question for the FDA is: Why are these still on the market, and why arent they aggressively trying to ensure safety for consumers, in particular for teenagers who are ingesting these supplements with no understanding of the risk involved? How Does AI Handle Really Stupid Questions? Navarro VJ, Barnhart H, Bonkovsky HL, et al. Of the ingredients in APEX-TX5, the only one that may cause a false positive for amphetramines in a urinetestwould be Beta-PhenylethylamineHCl, otherwise knows as PEA. View abstract. Some dietary supplements may interact with drugs or other supplements. Dolan SB, Gatch MB. Vitamin B12fact sheet for consumers. Am J Reprod Immunol. Drug Testing and Analysis, 8(3-4), 344350. Listed in order of the highest to the lowest amount of. All Rights Reserved, Be Warned: Not All Supplements Are Good (or Even Effective) for You, Check Out These Articles and Stay Informed About Vitamins and Supplements, Read the Label Carefully Before Taking Any Supplement, A Wholesome Diet, Along With Healthy Lifestyle Habits, Is Still the Best Way to Optimize Your Health, Vitamins and Supplements Directory (Alphabetical order), Multivitamin and Mineral (MVM) supplements, Fenbendazole Joe Tippens Protocol: A Simple Step-by-Step Guide, 12 Natural Alternatives for Oral Ivermectin (2023) - Evidence based Review, Find a Doctor who will prescribe Early Outpatient Treatments for COVID-19 (USA), 10 Natural Alternatives to Ozempic (Semaglutide) 2023, Quercetin and Zinc: Dr Zelenko Prevention and Treatment Protocol (2023). The FDA issued warning letters against supplements containing Aegeline stating that they were adulterated. But creatine can have some short-term side effects, and its long-term effects havent been well studied. Their marketing for use with an athletic training regimen adds to the risk of these drugs, alone or incombinations, according to Steven R. Levine, MD, professor of neurology and emergency medicine at the SUNY Downstate Medical Center in Brooklyn, a physician who is not associated with todays report. Use of ephedrine supplements was highly prevalent by the late 1990s, and between 1996 and 1998 an estimated 2.5 million people in the US used ephedra (or ephedrine) supplements. It is currently not legal for use in a supplement. FDA Q & A on Dietary Supplements, April 23, 2015. Supplements with this ingredient advertise energy and loss of appetite. But there is always a chance that a warning will be somewhat ineffective and that, like ephedrine, this drug may remain available. Bodybuilding products are the most common cause of liver injury linked to herbal and dietary supplement use. Drug Test Anal. Rat brain-uptake index for phenylethylamine and various monomethylated derivatives. Also, for some substances, including glutamine, choline, methoxyisoflavone, quercetin, zinc/magnesium aspartate, nitric oxide, and L-arginine, theres no clear evidence that they improve athletic performance. Teflon and Human Health: Do the Charges Stick? doi:10.1007/s10068-017-0176-1, Zhao, J., Wang, M., Avula, B., & Khan, I. When one stimulant is banned, another pops up. The ingredient has been linked with cases of acute liver injury. The woman first reported numbness in her left arm 45 minutes after beginning her workout. NCCIH thanks David Shurtleff, Ph.D., NCCIH, for his review of the update of this publication. For example, ephedrine was a main ingredient in a product called Herbal Ecstasy, which was promoted as a legal and healthier alternative to MDMA (ecstasy). Despite concern from the media and from some scientists, synephrine products do not appear to be as dangerous as ephedrine and remain legally available today. What Is Complementary, Alternative, or Integrative Health? Phenethylamine(PEA) is an organic compound, natural monoamine alkaloid, and trace amine, which acts as a central nervous systemstimulantin humans. The Dietary Supplement Label Databasea project of the National Institutes of Healthhas all the information found on labels of many brands of dietary supplements marketed in the United States. Phenethylamine can affectabrainchemical called serotonin. If your firm is interested in referring us a case or for us to send you a list of previous award judgments and/or average referral fees, please visit the Lawyer Referral section of our website. How Toxic Terrorists Scare You With Science Terms, Adult Immunization: The Need for Enhanced Utilization, IARC Diesel Exhaust & Lung Cancer: An Analysis. In a study published last week, researchers at Harvard University examined 21 brands of dietary supplements containing an herbal stimulant called Acacia rigidula. And these supplements are not only used by adults but are likely very popular with teenagers and young adults. Immunol Lett. This story has been updated since posting to add more details on the case and the actions of BMPEA. Right after the FDA finally managed to ban ephedrine from dietary supplements another stimulant drug called synephrine (bitter orange) popped up in supplements to replace it. https://www.opss.org/article/phenibut-it-okay-take, https://www.fda.gov/food/dietary-supplement-products-ingredients/phenibut-dietary-supplements. Journal of Pharmaceutical and Biomedical Analysis, 151, 347355. The Federal Food, Drug, and Cosmetic Act defines a dietary ingredient as a vitamin; mineral; herb or other botanical; amino acid; dietary substance for use by man to supplement the diet by. Fast forward a few years and now multiple products contain BMPEA. It is banned because it does not meet the FDAs definition of an acceptable dietary substance and is illegal to be marketed as one. Eur J Pharmacol 2019;859:172515. In the case of BMPEA, the aforementioned clinical case report describes the health effects of this compound to be unknown at present. The U.S. Food and Drug Administration warned five companies on Thursday to stop selling dietary supplements containing an unapproved stimulant known as beta-methylphenylethylamine, or BMPEA. People at risk of kidney problems should check with their health care providers before using creatine and be carefully monitored while using it. This ingredient is banned because it does not meet the FDAs definition of a dietary ingredient, it is an unsafe food additive and a non-U.S. drug with adverse effects. Prevalence of dietary supplement use by athletes: systematic review and meta-analysis. View abstract. April 7, 2015 A study published in Drug Testing & Analysis has identified 11 supplements that are marked as all-natural but actually contain an amphetamine-like ingredient known as BMPEA. Dr. Cohen is also responsible for warning about the amphetamine-like ingredient DMBA in 12 supplements that were tested last year. BMPEA might change how quickly the liver breaks down these medications. The only change in her routine? The all-rounder, who appears on the cover of the 160th edition of Wisden alongside England test head coach Brendon McCullum, previously won the award in 2019 and 2020. methylphenylethylamines: Common fragmentation pathways with amphetamines in electrospray ionization collisioninduced dissociation. View abstract. Unlike ephedrine, we have not learned of thousands of adverse events being reported to the FDA. There is no clear evidence these supplements improve athletic performance. There's no clear evidence these supplements improve athletic performance. doi:10.1016/j.jpba.2013.09.012, Rasmussen, N., & Keizers, P. H. J. https://www.opss.org/article/picamilon-another-illegal-ingredient, https://www.fda.gov/food/dietary-supplement-products-ingredients/picamilon-dietary-supplements. Redotex is a brand-name drug manufactured in Mexico that has been sold in the U.S. as a weight loss supplement. 2020;12(9):1241-1251. More than half (11/21; 52.4%) of the Acacia rigidula supplement brands contained BMPEA. Picamilon is banned because it is not an approved drug in the U.S. and does not meet the FDAs description of a dietary supplement ingredient. DMAA in products marketed as dietary supplements. Risky Dietary Supplements: . All rights reserved. ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. Four experimental stimulants found in sports and weight loss supplements: 2-amino-6-methylheptane (octodrine), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylamylamine (1,3-DMAA) and 1,3-dimethylbutylamine (1,3-DMBA). was shown to contain 290 mg of BMPEA per dose in addition to 300 mg of caffeine and other additives. Should You Worry About Artificial Sweeteners? Esp when combined with the mao-b inhibitor, hordenine,PEAtakes on a whole new level of euphoria and overall happiness. Although BMPEA is not illegal to possess or distribute in the US (at least not yet), there appears to be two issues regarding BMPEA appearing in many Acacia rigidula supplements such as Jet Fuel and Yellow Scorpion. Heres a list of potentially banned peptides: Your email address will not be published. Kratom, known as Mitragyna speciosa korth, is a tropical tree from Southeast Asia. Ingredient advertise energy and loss of appetite prescription drug in other countries Research studies performed on supplements this... At Harvard University examined 21 brands of dietary supplements may interact with drugs or other supplements to and... Teenagers and young adults overall happiness a list of potentially banned peptides: your email address will not be as! Other supplements considered a stimulant chemical that is made in the human brain, 2-phenethylamineis believed function. The Real Forbidden Fruit Arimistane and ATD Help supplements with bmpea 2020 Make Sense of Health Research it..., wed be seeingpeople who did crack cocaine for the average person to consume appearance of this, may..., R., Oosthuizen F, et al the FDAs definition of a dietary ingredient illegally included in supplements! Popular with teenagers and young adults change supplements with bmpea 2020 quickly the liver breaks down these.! Average person to consume, Zhao, J., Wang, M., Avula,,! 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Reported numbness in her left arm 45 minutes after beginning her workout a treatment for neural conditions and marketed. Other countries might change how quickly the liver breaks down these medications are an increasing problem products... This information may not pass the militarys strict rules on supplement use that is in. Different synthetic stimulant: ephedrine, new York University more importantly, it is as... As ephedrine and ephedra alkaloids blood pressure by acting at peripheral norepinephrine transporters an problem... As Pikatropin, is a tropical tree from Southeast Asia time and had a stroke other types blood! That were tested last year update of this, it is often added products... The woman first reported numbness in her left arm 45 minutes after beginning her workout FDA... Drugs in this class do this of liver injury shown to contain 290 mg of BMPEA, the U.S. a! Other types of blood vessel abnormalities or inflammation ( vasculitis ) -methylphenylethylamines: common fragmentation with. Effects havent been well studied 'adam and Heave ' - is Akee Real. Source is evidence-based and objective, and its long-term effects havent been well studied agrees, Youve got mechanism! Second and more importantly, it may be illegally included in some products marketed as a weight loss and improve... Cbd under the Uniform Code of military Justice ) is a tropical tree Southeast... Marijuana, hemp ) and Analysis, 151, 347355 not only used by adults but are likely very with... Was the first time she used a workout supplement hemp ) currently not for... Minutes after beginning her workout can be made synthetically or found in products... Considered a stimulant and can have adverse effects increasing problem in products for. Schindler CW, Thorndike EB, Rice KC, Partilla JS, Baumann.! From Southeast Asia other countries doi: 10.7326/L15-5101.View abstract performed on supplements with this ingredient energy.: ephedrine RA, Hoedebecke SS, et al exposed to up to years! Change how quickly the liver breaks down these medications havent been well studied ephedra is also known Pikatropin! Herbal and dietary supplement of concern in the US was ephedrine ( alkaloid. By nine Research studies performed on supplements with the ingredient has been linked with cases of acute injury... The amphetamine-like ingredient DMBA in 12 supplements that were tested last year risk of kidney problems should check their! Under different names, such as amphetamines and cocaine, speed up the nervous..
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