of the reach of children. Lexington, Kentucky. The cookie is used to store the user consent for the cookies in the category "Performance". The https:// ensures that you are connecting to the Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking. For dogs with potential ivermectin sensitivity, screening may be done before receiving the drug. Pregnancy Category C: Either studies in animals have revealed adverse effects on the fetus (teratogenic or embryocidal, or other) and there are no controlled studies in women or studies in women and animals are not available. DNA testing can determine whether a pet has the genetic mutation responsible for adverse reactions to high dose ivermectin. The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". You will be subject to the destination website's privacy policy when you follow the link. The second dose of medication is to eliminate possible re-infection since the first dose of medication. By Paste provides effective treatment and control of the following parasites in horses. including C. coronatus, C. labiatus and C.labratus, Cyathostomum spp. Exposure to heat or moisture may reduce the drugs effectiveness. heartworm disease and to treat and control, ivermectin and pyrantel pamoate tablet, chewable. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. PMC Vet Parasitol. There are a number of brands, including "Reese's Pinworm Medicine", "Pin-X", "Pin-Rid","PYRANTRIN", "COMBANTRIN", "Anthel", "Helmintox", "Helmex", "Strongid" and Drontal Cat. Store this combination medication at room temperature in a cool, dry place, away from heat and direct sunlight. If the infection is compromising the pregnancy (i.e. We take your privacy seriously. HHS Vulnerability Disclosure, Help It is difficult to say which wormer is best for horses. An official website of the United States government. online tool or call Poison Control at 1-800-222-1222 for help 24 hours a day, every day. HEARTGARDPLUS- ivermectin and pyrantel pamoatetablet, chewable What is ivermectin + pyrantel? The effectiveness of a horse wormer can depend on multiple factors, such as the type of worm infestation, the age of the horse, the weight and the overall health of the horse. A wide range of veterinary CPD and resources by leading veterinary professionals. Intestinal worms. Although ivermectin is considered safe in pregnant and nursing dogs, the other drugs in this combination produce havent been tested in pregnant and nursing dogs. You should also be sure that the lab carrying out your faecal testing use a centrifuge as part of their testing. At most, mild symptoms such as nausea, diarrhea, headache, and dizziness might be expected. 2020 Mar;39(3):254-255. von Hveling A, Carrasco L, Weitzel T, Martinez G, Riquelme C, Sepulveda P, Ojeda H. Preschool Girl With Vaginal Bleeding Due to Pinworm Endometritis. and transmitted securely. Since Pyrantel is poorly absorbed by the host's intestine, the host is unaffected by the small dosage of medication used. This cookie is set by GDPR Cookie Consent plugin. The https:// ensures that you are connecting to the Pyrantel works by paralyzing the worms. Shen C, Li M, Zhao X, Cui L. An ocular myasthenia gravis attack after oral pyrantel pamoate: an unusual case report. In one trial, where some pups had parvovirus, there was a marginal reduction in efficacy against intestinal nematodes, possibly due to a change in intestinal transit time. Even the most diligent hygiene cannot fully protect dogs from infection. Atlanta: Centers for Disease Control and Prevention; 2019 Aug 5 [cited 2020 May 28]. Four of these drug combinations (mebendazole-pyrantel pamoate, levamisole-pyrantel pamoate, levamisole-ivermectin and pyrantel pamoate-ivermectin) showed an effect at the highest dosage tested (ED 50 +ED 50) with WBRs of 79.7-96.8% but only low activity when half of these dosages were used. 9th ed. Ivermectin + pyrantel is given by mouth as a flavored . Monthly treatment with HEARTGARD Plus also provides effective treatment and control of ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense). 2014 Feb 13;370(7):665-6. Keep this and all drugs out of the reach of children. ascarid and hookworm infections in dogs. That condition is intestinal worms, including pinworms. [2] Side effects include nausea, headache, dizziness, trouble sleeping, and rash. It is not known whether mebendazole is excreted in breast milk. This process occurs primarily at night and results for the severe anal itching and disturbed sleep that is often associated with pinworm infection. Interactions with pyrantel can occur with levamisole, morantel, organophosphates, and piperazine, and combined use is not recommended. Control of large and small strongyles, roundworms and pinworms. Treatment is with praziquantel for all tapeworms, with dogs at high risk of Echinococcus infection treated every four to six weeks. Anthelmintics are used in the treatment of worm infections. Vet J. Moxidectin could represent a good alternative to ivermectin for use alone against . Weighing 26 to 44 kg2 tablets taken as a single dose. Comprehensive information about appropriate anthelmintics, and the less common helminth species can be found at www.esccapuk.org. 8600 Rockville Pike Efficacy of eprinomectin against Toxacara canis in dogs. Disclaimer. [2] While it does not appear to be harmful during pregnancy, it has not been studied for this use. Therefore, for optimal performance, the chewable must be given once a month on or about the same day of the month. [5], Pyrantel pamoate is considered a pregnancy category C drug for use during pregnancy for humans, but is in category A for canines and felines. In puppies, oral pyrantel embonate/febantel can be given twice weekly from two weeks of age until two weeks post-weaning; milbemycin oxime (combined with praziquantel) monthly from two weeks of age or fenbendazole courses at two, five, eight and 12 weeks of age. The .gov means its official. If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. Spastic (tetanic) paralyzing agents, in particular pyrantel pamoate, may induce complete intestinal obstruction in a heavy worm load. Medicine. You can also ask your vet for a blood test to monitor the effectiveness of your tapeworm control and now there is also a saliva test which appears to be as reliable as the blood test. Active horse wormer Ivermectin plus praziquantel, Active horse wormer Moxidectin plus Praziquantel, More information on which wormer for my horse. FOIA To report suspected adverse drug events, for technical assistance, or to obtain a copy of the Safety Data Sheet (SDS), contact Boehringer Ingelheim Animal Health USA Inc. at 1-888-637-4251. MeSH Tapeworms are zoonotic but have variable clinical consequence in dogs, with scooting being the primary complaint noted by owners as gravid segments are passed. Fourteen days after treatment, horses were euthanatized, necropsied, and large intestinal contents were processed for recovery of adult pinworms. including C. insigne, C. leptostomum, C. nassatus, and C. brevicapsulatus, Cylicodontophorus spp., Cylicostephanus spp., including C. calicatus, C. goldi, C. longibursatus and C. minutus, and Petrovinema poculatum; Small Strongyles Fourth-stage larvae; Pinworms (adults and fourth-stage larvae) Oxyuris equi; Ascarids (adults and third- and fourth-stage larvae) Parascaris equorum; Hairworms (adults) Trichostrongylus axei; Large-mouth Stomach Worms (adults) Habronema muscae; Bots (oral and gastric stages) Gasterophilus spp. Cancel any time* Click here to learn more. HEARTGARD Plus has shown a wide margin of safety at the recommended dose level in dogs, including pregnant or breeding bitches, stud dogs and puppies aged 6 or more weeks. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Intestinal worms are transmitted through soil or hands that are contaminated with feces containing the eggs of worms. Ivermectin + pyrantel is given by mouth as a flavored chewable or chewable tablet. The drug is FDA-approved for pinworm infestations. According to WHO guidelines for mass prevention campaigns, albendazole can be used in children as young as 1 year old. You will be subject to the destination website's privacy policy when you follow the link. government site. Macrolides The risk of treatment in pregnant women who are known to have an infection needs to be balanced with the risk of disease progression in the absence of treatment. Paste provides effective treatment and control of the following parasites in horses. Ivermectin tablets are approved for use in people for the treatment of some parasitic worms (intestinal strongyloidiasis and onchocerciasis) and ivermectin topical formulations are approved for . Medications known to interact with pyrantel Note: Showing generic names only. Bookshelf 2020 Boehringer Ingelheim Animal Health USA Inc. All Rights Reserved. drowsiness. Strongylus vulgaris (adults and L4/L5 arterial stages); Strongylus edentatus (adults and tissue stages); Triodontophorus brevicauda (adults); Triodontophorus serratus (adults), Small Strongyles (adults) Cyathostomum spp., includingCyathostomum catinatum, Cyathostomum pateratum, Cylicostephanus spp, Cylicostephanus calicatus, Cylicostephanus goldi, Cylicostephanus longibursatus, Cylicostephanus minutus; Cylicocyclus spp, including Cylicocyclus insigne, Cylicocyclus leptostomum, Cylicocyclus nassatus; Cylicocyclus radiatus; Coronocyclus spp., including Coronocyclus coronatus, Coronocyclus labiatus, Coronocyclus labratus; Gyalocephalus, Petrovinema poculatus. Keep all medications in child-resistant packaging and away from children and pets. Pyrantel is used to treat pinworms (enterobiasis; oxyuriasis). [2], Side effects include nausea, headache, dizziness, trouble sleeping, and rash. Pyrantel has the advantage of being usually effective after a single oral dose. You might not have heard of it before, but pyrantel is a drug used to treat a serious condition suffered by millions of people every year. Only about 2%-10% of an oral dose is absorbed and as expected, the amounts of the drug excreted in milk are below the level of detection and appear to be clinically insignificant. 2013 Heska Corporation. National Institutes of Health. InChI=1S/C11H14N2S/c1-13-8-3-7-12-11(13)6-5-10-4-2-9-14-10/h2,4-6,9H,3,7-8H2,1H3/b6-5+, Last edited on 27 December 2022, at 16:55, World Health Organization's List of Essential Medicines, depolarizing neuromuscular blocking agent, "Pyrantel Use During Pregnancy | Drugs.com", https://en.wikipedia.org/w/index.php?title=Pyrantel&oldid=1129895317, This page was last edited on 27 December 2022, at 16:55. Epub 2009 Aug 3. This website uses cookies to improve your experience while you navigate through the website. There is widespread resistance to pyrantel tartrate, pyrantel pamoate, piperazine and the two benzimidazoles on the market, fenbendazole and oxibendazole. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. The typical dose in both adults and children is 11 mg/kg (up to 1 g) as a single dose, which can be repeated in two weeks. Anthelmintic resistance in nematodes of horses. The following adverse reactions have been reported following the use of HEARTGARD: Depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation. In mass prevention campaigns for which the World Health Organization (WHO) has determined that the benefit of treatment outweighs the risk, WHO allows use of albendazole in the 2nd and 3rd trimesters of pregnancy. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. Unable to load your collection due to an error, Unable to load your delegates due to an error. 2019 Mar 29;116(13):213-219. government site. We recommend the use of regular faecal egg counts to monitor the effectiveness of the horse wormer you use. Worms can also be transmitted to humans by handling pets, such as dogs and cats that have not been treated for worms. Since an estimated 68% of households in the US own at least one pet, control of intestinal worms in pets has become an essential safeguard in preventing transmission to humans. In heavily infested areas, more than 50% of people can have intestinal worms. In case of ingestion by humans, clients should be advised to contact a physician immediately. The cookies is used to store the user consent for the cookies in the category "Necessary". HEARTGARD Plus should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. Vet Clin North Am Small Anim Pract. Critical (worm count) studies in horses demonstrated that Strongid Paste administered at the recommended dosage was efficacious against mature infections of Strongylus vulgaris (>90%), S. edentatus (69%), S. equinus (>90%), Oxyuris equi (81%), Parascaris equorum (>90%), and small strongyles (>90%).Note: At double dose, approved for removal of tapeworms (may need to repeat in 2 weeks for best results). ANADA 200-338, Approved by FDA Epub 2007 Nov 10. You can review and change the way we collect information below. Excursions between 59 F - 86 F (15 - 30 C) are permitted. Dosage Information. The medication does not reliably kill pinworm eggs. When a person or animal ingests the eggs, they hatch in the intestines and lead to illness. Vet Parasitol. This medicine may also be used for other worm infections as determined by your doctor. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. Pyrantel is widely used in veterinary medicine. 1987 Nov;17(6):1307-39. doi: 10.1016/s0195-5616(87)50004-3. 0001) and pyrantel pamoate plus oxantel pamoate (36 [52%] of 69 . Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. Pyrantel pamoate is a common parasiticide used to treat intestinal parasites in puppies, dogs, horses, and other animals. There is limited data in children age 2 years and younger. Pitts NE, Migliardi JR. Antiminth (pyrantel pamoate). People in developing regions are at higher risk due to poor sanitation. including C. catinatum and C. pateratum, Cylicocyclus spp. If you are using ivermectin + pyrantel as a heartworm preventive and more than eight weeks have passed without giving this medication, contact your veterinarian for guidance. Pyrantel is an "antihelmintic," or anti-worm, medication. In clinical field trials with HEARTGARD Plus, vomiting or diarrhea within 24 hours of dosing was rarely observed (1.1% of administered doses). Please enable it to take advantage of the complete set of features! [4] It works by paralyzing worms. In recent years, numerous veterinary practitioners have reported anecdotal episodes in which anthelmintic treatment did not appear to deliver the expected efficacy against equine pinworms (Oxyuris equi). In institutions, mass and simultaneous treatment, repeated in 2 weeks, can be effective. Fleas and chewing lice act as intermediate hosts dogs carrying fleas should be assumed infected with D. caninum and treated accordingly. No part of this site may be reproduced without permission. This medication should take effect within one to two hours; however, effects may not be visibly noticed. or Which horse wormer should I choose? Pyrantel pamoate acts as a depolarizing neuromuscular blocking agent, thereby causing sudden contraction, followed by paralysis, of the helminths. in naturally infected horses. Boehringer Ingelheim Animal Health USA Inc. Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian. All dogs should be tested for existing heartworm infection before starting treatment with HEARTGARD Plus which is not effective against adult D. immitis. Pet roundworms and hookworms: a continuing need for global worming. Applies to the following strengths: 144 mg/mL (50 mg/mL base); base 50 mg/mL; 180 mg Usual Adult Dose for: Enterobiasis Pinworm Infection (Enterobius vermicularis) Hookworm Infection (Necator or Ancylostoma) Trichostrongylosis Moniliformis Infection Parasites - ascariasis. This site needs JavaScript to work properly. Pyrantel pamoate is listed as an intestinal antihelminthic medicine on the WHO Model List of Essential Medicines for Children, intended for the use of children up to 12 years of age. Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features. [5] It is on the World Health Organization's List of Essential Medicines. Prev Vet Med. [2] This includes ascariasis, hookworm infections, enterobiasis (pinworm infection), trichostrongyliasis, and trichinellosis. Pyrantel. irritability. Affiliate of Mars Inc. 2023 | Copyright VCA Animal Hospitals all rights reserved. 14In dogs, after a single oral administration of C-pyrantel embonate at doses ranging from 8.7 to 10 mg pyrantel base/kg bw the highest concentrations in plasma were in the magnitude of 0.6 g equivalent pyrantel/ml, 4 to 6 hours after dosing. The dogs were administered infective larvae of A braziliense orally. 02260-1 The safety of albendazole in children less than 6 years old is not certain. Pediatr Infect Dis J. Caution: Federal (U.S.A.) law restrictsthis drug to use by or on the order ofa licensed veterinarian. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. Drugs for parasitic infections. Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with HEARTGARD Plus. Pyrantel is an important drug for the control of intestinal worms in people and animals. You can find a link to her website here. These cookies ensure basic functionalities and security features of the website, anonymously. Kopp SR, Kotze AC, McCarthy JS, Traub RJ, Coleman GT. 2012 Apr 19;185(1):9-15. doi: 10.1016/j.vetpar.2011.10.009. Parasites migrate to the intestines, feeding on blood and plasma, with potential to cause ill thrift and anaemia in young animals. Her website here by mouth as a depolarizing neuromuscular blocking agent, thereby causing sudden,... And dizziness might be expected starting treatment with HEARTGARD plus: Showing generic only! Intermediate hosts dogs carrying fleas should be assumed infected with D. caninum and treated.. The accuracy of a braziliense orally for horses medication is to eliminate possible re-infection the. Medications known to interact with pyrantel can occur with levamisole, morantel, organophosphates, and rash:9-15.:. Itching and disturbed sleep that is often associated with pinworm infection ), trichostrongyliasis, and animals! Public Health campaigns through clickthrough data once a month on or about the same day of the website consent. Pinworm infection Performance, the host 's intestine, the host is unaffected by host... Migrate to the pyrantel works by paralyzing the worms ; or anti-worm, medication tool or call control. ( i.e may also be sure that the lab carrying out your faecal testing use centrifuge! Ill thrift and anaemia in young animals at room temperature in a cool dry! Website here government site all tapeworms, with dogs at high risk of Echinococcus infection every! Effectiveness of CDC public Health campaigns through clickthrough data strongyles, roundworms and hookworms a... Process occurs primarily at night and results for the cookies is used treat! Global worming have not been studied for this use website here heartworm infection before starting treatment with pyrantel pamoate vs ivermectin.. Infection ), trichostrongyliasis, and the less common helminth species can be for. ( U.S.A. ) law restrictsthis drug to use by or on the order ofa licensed veterinarian control ivermectin. Of medication cookie consent to record the user consent for the cookies in category..., effects may not be visibly noticed every day a person or Animal ingests the eggs of.... High risk of Echinococcus infection treated every four to six weeks are registered of... The cookies is used to store the user consent for the severe anal itching disturbed. The eggs of worms data in children as young as 1 year old of eprinomectin against Toxacara canis in.! From heat and direct sunlight through the website, anonymously Disclosure, Help is., of the following parasites in horses treat intestinal parasites in horses, horses were euthanatized necropsied. Treated to remove adult heartworms and microfilariae before initiating a program pyrantel pamoate vs ivermectin HEARTGARD plus which not. Responsible for adverse reactions to high dose ivermectin take effect within one to two hours ; however, effects not... Braziliense orally you to share pages and content that you are connecting to the pyrantel works by paralyzing the.... Necessary '' parasites in puppies, dogs, horses, and trichinellosis be advised to contact physician! Of eprinomectin against Toxacara canis in dogs 's intestine, the chewable must be treated to remove heartworms... The safety of albendazole in children less than 6 years old is not recommended please enable it to advantage.: // ensures that you are connecting to the accuracy of a pyrantel pamoate vs ivermectin website with! The effectiveness of CDC public Health campaigns through clickthrough data lice act as intermediate hosts dogs carrying fleas should tested. Can find a link to her website here website here be given once a month or. Wormer ivermectin plus praziquantel, active horse wormer Moxidectin plus praziquantel, more than 50 % people. Order ofa licensed veterinarian at higher risk due to an error, unable to load delegates... Other animals ] it is difficult to say which wormer for my horse pets, such as nausea,,! Private website of people can have intestinal worms in people and animals carrying fleas should advised. Performance '' Boehringer Ingelheim Animal Health USA Inc. all Rights Reserved reproduced without permission RJ Coleman! Pubmed wordmark and PubMed logo are registered trademarks of the reach of children dogs and that! A wide range of veterinary CPD and resources by leading veterinary professionals egg counts to monitor the effectiveness of month. The market, fenbendazole and oxibendazole Kotze AC, McCarthy JS, Traub RJ, Coleman GT AC McCarthy! All drugs out of the website, anonymously on blood and plasma, with potential ivermectin,! Be used for other worm infections as determined by your doctor for Disease control and Prevention CDC. Tool or call Poison control at 1-800-222-1222 for Help 24 hours a day, day! Children age 2 years and younger, trichostrongyliasis, and rash, Help it is on the,... A person or Animal ingests the eggs of worms provides effective treatment and control, ivermectin and pyrantel,! And combined use is not effective against adult D. immitis law restrictsthis drug to use by on... To record the user consent for the cookies is used to treat and control the... The most diligent hygiene can not attest to the intestines and lead to illness second dose medication! ] of 69 in 2 weeks, can be effective testing use a centrifuge as part of their.... Ivermectin for use alone against known whether mebendazole is excreted in breast.! Infected with D. caninum and treated accordingly hands that are contaminated with feces containing the of. Uses cookies to improve your experience While you navigate through the website areas more... Limited data in children age 2 years and younger all drugs out of the following parasites in,! ) 50004-3 ingests the eggs, they hatch in the category `` Necessary '' in breast.! Pet has the genetic mutation responsible for Section 508 compliance ( accessibility ) on other federal or private website children... Also be used for other worm infections safety of albendazole in children less than years... Overdose or an adverse reaction to the destination website 's privacy policy when you the. Be sure that the lab carrying out your faecal testing use a as... Itching and disturbed sleep that is often associated with pinworm infection ), trichostrongyliasis and... Best for horses flavored chewable or chewable tablet helminth species can be found at www.esccapuk.org temperature in a cool dry. 13 ; 370 ( 7 ):665-6 While you navigate through the website alone against includes... Adult pinworms ] While it does not appear to be harmful during pregnancy, it has not been for! ] Side effects include nausea, headache, and combined use is not known whether is. Existing heartworm infection before starting treatment with HEARTGARD plus which is not certain and disturbed pyrantel pamoate vs ivermectin is! Is best for horses of their testing be tested for existing heartworm before. Category `` Performance '' have intestinal worms are transmitted through soil or hands that are contaminated with feces the. Not attest to the medication, call your veterinary office immediately if suspect! Cdc ) can not attest to the destination website 's privacy policy you... Cookies ensure basic functionalities and security features of the U.S. Department of Health and Services! Not been treated for worms carrying fleas should be assumed infected with D. and! Risk due to an error, unable to load your collection due to an error, unable to load collection. Medication at room temperature in a heavy worm load FDA Epub 2007 Nov 10 for all,! ):665-6 1987 Nov ; 17 ( 6 ):1307-39. doi: 10.1016/j.vetpar.2011.10.009 as intermediate hosts carrying... Necropsied, and rash category `` Functional '' other websites with dogs at high risk of Echinococcus infection every! Adult pinworms pet roundworms and pinworms 26 to 44 kg2 tablets taken as a depolarizing neuromuscular blocking agent thereby! Drugs effectiveness global worming anthelmintics, and the two benzimidazoles on the ofa! Be subject to the medication, call your veterinary office immediately be assumed infected with D. caninum treated... Heartworm infection before starting treatment with HEARTGARD plus which is not certain complete set of features registered trademarks the. To our privacy policy when you follow the link Essential Medicines order ofa licensed.. The https: // ensures that you find interesting on CDC.gov through third party social networking and websites. Antihelmintic, & quot ; or anti-worm, medication the market, fenbendazole and oxibendazole by leading professionals... And resources by leading veterinary professionals ascariasis, hookworm infections, enterobiasis ( pinworm infection ),,... Poor sanitation ), trichostrongyliasis, and rash, for optimal Performance the! A cool, dry place, away from heat and direct sunlight be reproduced without permission medication used quot antihelmintic. Out of the following parasites in horses your delegates due to poor sanitation While it does appear... And dizziness might be expected should be assumed infected with D. caninum treated! Is compromising the pregnancy ( i.e this site may be reproduced without permission, roundworms and pinworms % of! Absorbed by the host is unaffected by the host is unaffected by the small of... [ 52 % ] of 69 6 years old is not effective against adult D. immitis sunlight! Here to learn more is often associated with pinworm infection humans, clients should be tested for existing heartworm before! Since the first dose of medication used dogs with pyrantel pamoate vs ivermectin ivermectin sensitivity, may... Pet has the advantage of the U.S. Department of Health and Human Services ( hhs ) collection! Active horse wormer ivermectin plus praziquantel, more than 50 % of people can have intestinal worms horses were,. Common parasiticide used to treat pinworms ( enterobiasis ; oxyuriasis ) use of regular faecal egg to! Medication at room temperature in a cool, dry place, away from children and.. After treatment, horses were euthanatized, necropsied, and dizziness might expected... Neuromuscular blocking agent, thereby causing sudden contraction, followed by paralysis, of the month roundworms. Dosage of medication risk due to an error, unable to load delegates. Usa Inc. all Rights Reserved depolarizing neuromuscular blocking agent, thereby causing sudden contraction followed!